2 GPCRs : new opportunities and challenges for drug discovery
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منابع مشابه
Dissection of aberrant GPCR signaling in tumorigenesis--a systems biology approach.
The superfamily of G-protein-coupled receptors (GPCRs) is one of the largest mammalian protein families. It is involved in signal transduction and participates in the regulation of normal physiological function and pathological progression of a range of diseases. Recent studies have demonstrated that many aberrant GPCRs and their ligands are associated with tumorigenesis, angiogenesis and metas...
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During the past 10 years or so, associated with the introduction of molecular biology techniques to G protein-coupled receptor (GPCR) research, outstanding progress has been made in understanding the mechanisms of action of these key proteins and their physiological functions. in-vivo manipulation of levels of GPCRs using transgenic and gene knock-out approaches have been particularly successfu...
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Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery. Two promising orphan GPCRs are the endothelin B receptor-like proteins, GPR37 [ET(B)R-LP, Pael-R] and GPR37L1 [ET(B)R-LP-2]. Originally identified through searches for homologs of endothelin and bombesin receptors, neither...
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تاریخ انتشار 2012